Juventus are looking to avoid a fourth consecutive defeat to Sampdori in their first leg at Stadio San Paolo, and it could be the end of their run in Italy’s top-flight.
Juventus will have a big advantage against the hosts thanks to their impressive attacking options and their willingness to attack from set pieces.
The hosts will be well-disciplined and will try to force Juventus into making errors and take the advantage.
A first-half penalty to Simone Inzaghi gave Sampdora the lead with a stunning 25-yard free-kick which was parried away by Alessandro Florenzi, before the visitors doubled their lead from the penalty spot with a superb goal.
Sampdoria will be without Diego Callejon and Simone Padoin, who were both forced off against Milan on Wednesday and will miss their second consecutive game after failing to return from suspension.
The result means Juve have now gone three games without a win away from home and are the only team in Serie A to have won their first three home games away from the Stadiali.
The result was another blow for Milan, who had lost only one of their first seven league games this season.
Milan have dropped six of their last seven league matches, including three of their four away from Stadios San Paoli.